Pesticide exposure and risk of Parkinson's disease - a population-based case-control study evaluating the potential for recall bias
Identifieur interne : 001926 ( Main/Exploration ); précédent : 001925; suivant : 001927Pesticide exposure and risk of Parkinson's disease - a population-based case-control study evaluating the potential for recall bias
Auteurs : Kathrine Rugbjerg [Danemark] ; M. Anne Harris [Canada] ; HUI SHEN [Canada] ; Stephen A. Marion [Canada] ; Joseph K. C. Tsui [Canada] ; Kay Teschke [Canada]Source :
- Scandinavian journal of work, environment & health [ 0355-3140 ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Pesticide, Santé publique, Homme.
English descriptors
- KwdEn :
Abstract
Objective The aim of this study was to investigate whether pesticide exposure was associated with Parkinson's disease in a population-based case-control study in British Columbia, Canada. Methods Patients reimbursed for anti-parkinsonian agents were identified and screened for eligibility as cases. Controls were selected from the universal health insurance database, frequency-matched to the case sample by birth year, gender, and geographic region. A total of 403 cases and 405 controls were interviewed about their job, medical and personal habits histories, and beliefs about disease risk factors. Among those reporting pesticide exposure, an occupational hygiene review selected participants exposed "beyond background" (ie, above the level expected in the general population). Unconditional logistic regression was used to estimate associations for different pesticide categories. Results Of the cases, 74 (18%) self-reported pesticide exposure and 37 (9%) were judged to be exposed beyond background. Self-reported exposure was associated with increased risk [odds ratio (OR) 1.76, 95% confidence interval (95% CI) 1.15-2.70], however the risk estimate was reduced following the hygiene review when restricted to those considered exposed (OR 1.51, 95% CI 0.85-2.69). When agricultural work was added to the model, the risk for hygiene-reviewed pesticide exposure was not elevated (OR 0.83, 95% CI 0.43-1.61), but agricultural work was (OR 2.47, 95% CI 1.18-5.15). More than twice as many cases as controls thought chemicals cause Parkinson's disease. Discussion This study provides little support for pesticide exposure as a cause of Parkinson's disease. The observed pattern of step-wise decreases in risk estimates might indicate differential recall by case status. The relationship to agricultural jobs suggests that farming exposures - other than pesticides - should be considered as risk factors for Parkinson's disease.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000274
- to stream PascalFrancis, to step Curation: 000989
- to stream PascalFrancis, to step Checkpoint: 000240
- to stream Main, to step Merge: 001A15
- to stream Main, to step Curation: 001926
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Pesticide exposure and risk of Parkinson's disease - a population-based case-control study evaluating the potential for recall bias</title><author><name sortKey="Rugbjerg, Kathrine" sort="Rugbjerg, Kathrine" uniqKey="Rugbjerg K" first="Kathrine" last="Rugbjerg">Kathrine Rugbjerg</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Danish Cancer Society, Institute of Cancer Epidemiology</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>1 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Harris, M Anne" sort="Harris, M Anne" uniqKey="Harris M" first="M. Anne" last="Harris">M. Anne Harris</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Hui Shen" sort="Hui Shen" uniqKey="Hui Shen" last="Hui Shen">HUI SHEN</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Marion, Stephen A" sort="Marion, Stephen A" uniqKey="Marion S" first="Stephen A." last="Marion">Stephen A. Marion</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Tsui, Joseph K C" sort="Tsui, Joseph K C" uniqKey="Tsui J" first="Joseph K. C." last="Tsui">Joseph K. C. Tsui</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Pacific Parkinson's Research Centre, University of British Columbia</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Teschke, Kay" sort="Teschke, Kay" uniqKey="Teschke K" first="Kay" last="Teschke">Kay Teschke</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0443303</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0443303 INIST</idno><idno type="RBID">Pascal:11-0443303</idno><idno type="wicri:Area/PascalFrancis/Corpus">000274</idno><idno type="wicri:Area/PascalFrancis/Curation">000989</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000240</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000240</idno><idno type="wicri:doubleKey">0355-3140:2011:Rugbjerg K:pesticide:exposure:and</idno><idno type="wicri:Area/Main/Merge">001A15</idno><idno type="wicri:Area/Main/Curation">001926</idno><idno type="wicri:Area/Main/Exploration">001926</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Pesticide exposure and risk of Parkinson's disease - a population-based case-control study evaluating the potential for recall bias</title><author><name sortKey="Rugbjerg, Kathrine" sort="Rugbjerg, Kathrine" uniqKey="Rugbjerg K" first="Kathrine" last="Rugbjerg">Kathrine Rugbjerg</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Danish Cancer Society, Institute of Cancer Epidemiology</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>1 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Harris, M Anne" sort="Harris, M Anne" uniqKey="Harris M" first="M. Anne" last="Harris">M. Anne Harris</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Hui Shen" sort="Hui Shen" uniqKey="Hui Shen" last="Hui Shen">HUI SHEN</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Marion, Stephen A" sort="Marion, Stephen A" uniqKey="Marion S" first="Stephen A." last="Marion">Stephen A. Marion</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Tsui, Joseph K C" sort="Tsui, Joseph K C" uniqKey="Tsui J" first="Joseph K. C." last="Tsui">Joseph K. C. Tsui</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Pacific Parkinson's Research Centre, University of British Columbia</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Teschke, Kay" sort="Teschke, Kay" uniqKey="Teschke K" first="Kay" last="Teschke">Kay Teschke</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Scandinavian journal of work, environment & health</title><title level="j" type="abbreviated">Scand. j. work, environ. & health</title><idno type="ISSN">0355-3140</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Scandinavian journal of work, environment & health</title><title level="j" type="abbreviated">Scand. j. work, environ. & health</title><idno type="ISSN">0355-3140</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Agriculture</term><term>British Columbia</term><term>Case control study</term><term>Cognitive bias</term><term>Epidemiology</term><term>Exposure</term><term>Human</term><term>Occupational exposure</term><term>Occupational history</term><term>Parkinson disease</term><term>Pesticides</term><term>Population</term><term>Public health</term><term>Risk factor</term><term>Self evaluation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pesticide</term><term>Exposition</term><term>Facteur risque</term><term>Santé publique</term><term>Population</term><term>Etude cas témoin</term><term>Maladie de Parkinson</term><term>Epidémiologie</term><term>Homme</term><term>Biais cognitif</term><term>Exposition professionnelle</term><term>Agriculture</term><term>Colombie britannique</term><term>Histoire professionnelle</term><term>Autoévaluation</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Pesticide</term><term>Santé publique</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective The aim of this study was to investigate whether pesticide exposure was associated with Parkinson's disease in a population-based case-control study in British Columbia, Canada. Methods Patients reimbursed for anti-parkinsonian agents were identified and screened for eligibility as cases. Controls were selected from the universal health insurance database, frequency-matched to the case sample by birth year, gender, and geographic region. A total of 403 cases and 405 controls were interviewed about their job, medical and personal habits histories, and beliefs about disease risk factors. Among those reporting pesticide exposure, an occupational hygiene review selected participants exposed "beyond background" (ie, above the level expected in the general population). Unconditional logistic regression was used to estimate associations for different pesticide categories. Results Of the cases, 74 (18%) self-reported pesticide exposure and 37 (9%) were judged to be exposed beyond background. Self-reported exposure was associated with increased risk [odds ratio (OR) 1.76, 95% confidence interval (95% CI) 1.15-2.70], however the risk estimate was reduced following the hygiene review when restricted to those considered exposed (OR 1.51, 95% CI 0.85-2.69). When agricultural work was added to the model, the risk for hygiene-reviewed pesticide exposure was not elevated (OR 0.83, 95% CI 0.43-1.61), but agricultural work was (OR 2.47, 95% CI 1.18-5.15). More than twice as many cases as controls thought chemicals cause Parkinson's disease. Discussion This study provides little support for pesticide exposure as a cause of Parkinson's disease. The observed pattern of step-wise decreases in risk estimates might indicate differential recall by case status. The relationship to agricultural jobs suggests that farming exposures - other than pesticides - should be considered as risk factors for Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Danemark</li></country><region><li>Hovedstaden</li></region><settlement><li>Copenhague</li></settlement></list><tree><country name="Danemark"><region name="Hovedstaden"><name sortKey="Rugbjerg, Kathrine" sort="Rugbjerg, Kathrine" uniqKey="Rugbjerg K" first="Kathrine" last="Rugbjerg">Kathrine Rugbjerg</name></region></country><country name="Canada"><noRegion><name sortKey="Harris, M Anne" sort="Harris, M Anne" uniqKey="Harris M" first="M. Anne" last="Harris">M. Anne Harris</name></noRegion><name sortKey="Hui Shen" sort="Hui Shen" uniqKey="Hui Shen" last="Hui Shen">HUI SHEN</name><name sortKey="Marion, Stephen A" sort="Marion, Stephen A" uniqKey="Marion S" first="Stephen A." last="Marion">Stephen A. Marion</name><name sortKey="Teschke, Kay" sort="Teschke, Kay" uniqKey="Teschke K" first="Kay" last="Teschke">Kay Teschke</name><name sortKey="Tsui, Joseph K C" sort="Tsui, Joseph K C" uniqKey="Tsui J" first="Joseph K. C." last="Tsui">Joseph K. C. Tsui</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001926 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001926 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:11-0443303
|texte= Pesticide exposure and risk of Parkinson's disease - a population-based case-control study evaluating the potential for recall bias
}}
| This area was generated with Dilib version V0.6.29. |  |